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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SETD2 All Species: 5.45
Human Site: S1252 Identified Species: 20
UniProt: Q9BYW2 Number Species: 6
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9BYW2 NP_054878.5 2564 287550 S1252 H V D G L H S S E E L R N L G
Chimpanzee Pan troglodytes XP_516423 2549 285788 W1245 E E L R N L G W D F S Q E K P
Rhesus Macaque Macaca mulatta XP_001113652 2550 286209 S1238 R V D G L H S S E E L R N L G
Dog Lupus familis XP_864158 2562 287091 E1249 V D G F H S S E E L R N L G W
Cat Felis silvestris
Mouse Mus musculus
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_418510 2354 262767 R1112 W D A R S A G R P A G G N Y E
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783359 3042 342758 T1311 E V S V K P P T L S Q M D V S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q2LAE1 1759 193210 N517 E I F L Q S N N I P Y D G P P
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.6 96.9 92 N.A. N.A. N.A. N.A. N.A. 61.7 N.A. N.A. N.A. N.A. N.A. N.A. 24.7
Protein Similarity: 100 98.9 98 94.6 N.A. N.A. N.A. N.A. N.A. 71.5 N.A. N.A. N.A. N.A. N.A. N.A. 41.6
P-Site Identity: 100 0 93.3 13.3 N.A. N.A. N.A. N.A. N.A. 6.6 N.A. N.A. N.A. N.A. N.A. N.A. 6.6
P-Site Similarity: 100 13.3 93.3 13.3 N.A. N.A. N.A. N.A. N.A. 6.6 N.A. N.A. N.A. N.A. N.A. N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. 20.7 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 35.9 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 0 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 15 0 0 15 0 0 0 15 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 29 29 0 0 0 0 0 15 0 0 15 15 0 0 % D
% Glu: 43 15 0 0 0 0 0 15 43 29 0 0 15 0 15 % E
% Phe: 0 0 15 15 0 0 0 0 0 15 0 0 0 0 0 % F
% Gly: 0 0 15 29 0 0 29 0 0 0 15 15 15 15 29 % G
% His: 15 0 0 0 15 29 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 15 0 0 0 0 0 0 15 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 15 0 0 0 0 0 0 0 0 15 0 % K
% Leu: 0 0 15 15 29 15 0 0 15 15 29 0 15 29 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 15 0 0 0 % M
% Asn: 0 0 0 0 15 0 15 15 0 0 0 15 43 0 0 % N
% Pro: 0 0 0 0 0 15 15 0 15 15 0 0 0 15 29 % P
% Gln: 0 0 0 0 15 0 0 0 0 0 15 15 0 0 0 % Q
% Arg: 15 0 0 29 0 0 0 15 0 0 15 29 0 0 0 % R
% Ser: 0 0 15 0 15 29 43 29 0 15 15 0 0 0 15 % S
% Thr: 0 0 0 0 0 0 0 15 0 0 0 0 0 0 0 % T
% Val: 15 43 0 15 0 0 0 0 0 0 0 0 0 15 0 % V
% Trp: 15 0 0 0 0 0 0 15 0 0 0 0 0 0 15 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 15 0 0 15 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _